nanotechnology rnai therapy rondel sirna drug delivery

nanobiotechnology arrowhead research calaa-01

clinical trial nano rondel sirna cancer rnai nanoparticles

Images provided by Mark E. Davis, California Institute of Technology
rondel sirna drug delivery
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Calando Pharmaceuticals

Calando's RONDEL delivery system extends the reach of RNAi therapy by answering the new field’s most pressing need — an effective and safe systemic delivery method.

CALAA-01, a formulation targeting cancer, combines Calando's proprietary drug delivery system, RONDEL, with an siRNA developed by Calando. CALAA-01 is currently undergoing a Phase 1 clinical trial at UCLA Medical Center in Los Angeles, California and START in San Antonio, Texas.

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RNAi Overview

RNA interference (RNAi) is a naturally occurring mechanism that inhibits gene expression in a highly selective, sequence specific way. Since its discovery little more than a decade ago, the potential of this mechanism to revolutionize medicine has sparked excitement in both the biotech and pharmaceutical industries. As a result of considerable investment, RNAi based therapeutics are entering the clinic with promising new treatments for diseases like macular degeneration, RSV and cancer.

Combined with a safe and effective delivery method, RNAi-based treatments for life threatening and fatal diseases like cancer, AIDS, hepatitis C, Huntington’s disease and others become possible.

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News

  • 04/27/11
    Arrowhead Research Announces RNAi Leader John J. Rossi, PH.D. to Join Calando Scientific Advisory Board Read
  • 01/18/11
    Arrowhead Increases Investment in RNAi Subsidiary Calando Pharmaceuticals Read
  • 09/29/10
    Arrowhead Ceo Provides Update on Company Strategy and Milestone Achievements Read
  • 09/23/10
    Arrowhead Increases Ownership in RNAi Subsidiary Calando Pharmaceuticals, Inc. Read
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biotech calaa-01 calandoCalando Pharmaceuticals, Inc. is a majority-owned subsidiary of Arrowhead Research Corporation.

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